“Neuronal Growth
نویسندگان
چکیده
منابع مشابه
Guiding neuronal growth with light.
Control over neuronal growth is a fundamental objective in neuroscience, cell biology, developmental biology, biophysics, and biomedicine and is particularly important for the formation of neural circuits in vitro, as well as nerve regeneration in vivo [Zeck, G. & Fromherz, P. (2001) Proc. Natl. Acad. Sci. USA 98, 10457-10462]. We have shown experimentally that we can use weak optical forces to...
متن کاملAxon Stretch Growth: The Mechanotransduction of Neuronal Growth
During pre-synaptic embryonic development, neuronal processes traverse short distances to reach their targets via growth cone. Over time, neuronal somata are separated from their axon terminals due to skeletal growth of the enlarging organism (Weiss 1941; Gray, Hukkanen et al. 1992). This mechanotransduction induces a secondary mode of neuronal growth capable of accommodating continual elongati...
متن کاملNeuronal polarity: consolidation for growth, growth for consolidation
Axonal elongation involves the coordinated assembly and activation of molecular pathways in response to environmental signals. Neurons sense the environment at growth cones to decide on further growth, arborization or consolidation. The work by Ana Mingorance-Le Meur and Timothy P. O’Connor highlights the important role of neurite shaft dynamics in the consolidation process. The establishment o...
متن کاملSignaling Mechanisms Regulating Neuronal Growth Cone Dynamics
During the development of the nervous system, neurons migrate to their final location and extend neurites that navigate long distances in the extracellular environment to reach their synaptic targets. The proper functioning of the nervous system depends on correct connectivity, and mistakes in the wiring of the nervous system lead to brain abnormalities and mental illness. Growth cones are moti...
متن کاملEffects of Surface Asymmetry on Neuronal Growth
Detailed knowledge of how the surface physical properties, such as mechanics, topography and texture influence axonal outgrowth and guidance is essential for understanding the processes that control neuron development, the formation of functional neuronal connections and nerve regeneration. Here we synthesize asymmetric surfaces with well-controlled topography and texture and perform a systemat...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2005
ISSN: 0148-396X
DOI: 10.1227/01.neu.0000309499.00494.be